Genome-wide association study of prostate cancer-specific survival.
نویسندگان
چکیده
BACKGROUND Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. METHODS We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). RESULTS We observed no significant association between genetic variants and prostate cancer survival. CONCLUSIONS Common genetic variants with large impact on prostate cancer survival were not observed in this study. IMPACT Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.
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ورودعنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 24 11 شماره
صفحات -
تاریخ انتشار 2015